MOTS-C is a mitochondrial-derived peptide encoded within the 12S rRNA gene of mitochondrial DNA. This 16-amino-acid peptide has emerged as a significant subject in metabolic research, with studies demonstrating its role in activating the AMPK pathway — a master regulator of cellular energy homeostasis. Research has shown MOTS-C accumulates in skeletal muscle during metabolic stress and exercise, where it modulates glucose metabolism and fatty acid oxidation at the cellular level.

What makes MOTS-C remarkable to researchers is its origin: it is one of the few known peptides encoded by mitochondrial DNA rather than nuclear DNA. This positions it at the intersection of mitochondrial biology and metabolic signaling — a frontier that is reshaping our understanding of how cells regulate energy production, insulin sensitivity, and metabolic adaptation.

At 99%+ purity (HPLC verified), our MOTS-C is synthesized for research applications exploring mitochondrial-derived peptide signaling, AMPK pathway modulation, and cellular energy metabolism.